L-Cycloserine

L-Cycloserine is a potent inhibitor of serine palmitoyl transferase (SPT), the first enzyme in the sphingolipid synthesis pathway. It inhibits bacterial SPT activity by 80% at a concentration of 25 µM, which is 100 times more potent than D-cycloserine (Cay-22194). L-Cycloserine inhibits SPT activity up to 86% in a dose-dependent manner in microsomes prepared from mouse brain following administration of doses ranging from 25-200 mg/kg. It also inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat. L-Cycloserine inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation, and it does so more rapidly and potently than D-cycloserine (MICs = 0.3 and 2.3 µg/ml, respectively).Formal Name: 4S-amino-3-isoxazolidinone. CAS Number: 339-72-0. Synonyms: (-)-Cycloserine, (S)-Cycloserine, L-4-amino 3-Isoxazolidinone, Levcycloserine. Molecular Formula: C3H6N2O2. Formula Weight: 102.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 228 nm. SMILES: O=C1[C@@H](N)CON1. InChi Code: InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1. InChi Key: DYDCUQKUCUHJBH-REOHCLBHSA-N.