Juglanin

Juglanin is a flavonol that has been found in J. mandshurica and has diverse biological activities. It reduces the levels of reactive oxygen species (ROS) increased by oscillatory shear stress (OSS) in human aortic endothelial cells (HAECs) when used at concentrations of 2.5 and 5 µM. It also reduces OSS-induced increases in VCAM-1 and E-selectin protein levels in HAECs and decreases the attachment of THP-1 monocytes to HAECs. Juglanin (2.5, 5, and 10 µM) inhibits the proliferation of MCF-7 human breast cancer cells, as well as induces JNK activation, autophagosome formation, apoptosis, and cell cycle arrest at the G2/M phase in the same cells. It reduces tumor growth in an MCF-7 mouse xenograft model when administered at doses of 10 and 20 mg/kg. Juglanin (15 and 30 mg/kg) reduces body weight, renal fibrosis, and blood glucose levels, as well as serum and renal levels of Tnf-alpha, Il-1beta, Il-6, and chemokine (C-C motif) ligand 2 (Ccl2), and improves glucose tolerance in a mouse model of high-fat diet- and obesity-induced kidney disease.Formal Name: 3-(alpha-L-arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 5041-67-8. Synonyms: Kaempferol-3-O-arabinofuranose. Molecular Formula: C20H18O10. Formula Weight: 418.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(C(O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1)=C(C2=CC=C(C=C2)O)OC3=CC(O)=C4)C3=C4O. InChi Code: InChI=1S/C20H18O10/c21-7-13-15(25)17(27)20(29-13)30-19-16(26)14-11(24)5-10(23)6-12(14)28-18(19)8-1-3-9(22)4-2-8/h1-6,13,15,17,20-25,27H,7H2/t13-,15-,17+,20-/m0/s1. InChi Key: POQICXMTUPVZMX-UXYNSRGZSA-N. Origin: Plant/Juglans regia L..