Isolithocholic Acid

Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid (LCA, Cay-20253) or lithocholic acid 3alpha-sulfate (Cay-20676). Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid (TCA, Cay-16215) in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%. Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.Formal Name: (3beta,5beta)-3-hydroxy-cholan-24-oic acid. CAS Number: 1534-35-6. Synonyms: Isolithocholate, iso-LCA. Molecular Formula: C24H40O3. Formula Weight: 376.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Ethanol: slightly soluble, Methanol: slightly soluble. SMILES: C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17+,18+,19-,20+,21+,23+,24-/m1/s1. InChi Key: SMEROWZSTRWXGI-WFVDQZAMSA-N.