Isoleptospermone

Isoleptospermone is a polyketide synthase-derived beta-triketone that has been found in L. scoparium and has diverse biological activities. It inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD. IC50 = 14. µM for the A. thaliana enzyme). Isoleptospermone is active against B. subtilis and T. mentagrophytes (MICs = 2 and 1 µg/ml, respectively). It is lethal to T. ni and C. includens third-instar larvae (LC50s = 19. and 20. µg/larva, respectively) and induces foliar damage in cabbage, soybean, and corn. Isoleptospermone is also active against S. scabiei mites, young eggs, and mature eggs (LC50s = 59. 40. and 101. mM, respectively).