Hydroxyprogesterone Caproate

Hydroxyprogesterone caproate is a synthetic progestogen. In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-alpha-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-alpha and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats. Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Cay-80210) in pregnant mice. Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.Formal Name: 17-[(1-oxohexyl)oxy]-pregn-4-ene-3,20-dione. CAS Number: 630-56-8. Synonyms: 17-Caproxyprogesterone, HPC, Hormofort, Hydroxyprogesterone Hexanoate, NSC 17592, Progesterone Caproate, 17alpha-hydroxy Progesterone Caproate. Molecular Formula: C27H40O4. Formula Weight: 428.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 240, 244 nm. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(OC(CCCCC)=O)C(C)=O)=C1. InChi Code: InChI=1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1. InChi Key: DOMWKUIIPQCAJU-LJHIYBGHSA-N.