Hericene A

Hericene A is a polyketide synthase-derived geranyl resorcylate that has been found in H. erinaceus and has diverse biological activities. It is an inhibitor of alpha-glucosidase (IC50 = 6.7 µM). Hericene A (1-100 µM) decreases LPS-induced TNF-alpha, IL-6, and nitric oxide (NO) production in RAW 264.7 cells. It increases the axon length of primary rat hippocampal neurons and improves recognition memory in mice.. SMILES: CCCCCCCCCCCCCCCC(OCC1=CC(OC)=C(C(O)=C1C=O)C/C=C(C)/CC/C=C(C)\C)=O. InChi Code: InChI=1S/C35H56O5/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34(37)40-27-30-25-33(39-5)31(35(38)32(30)26-36)24-23-29(4)21-19-20-28(2)3/h20,23,25-26,38H,6-19,21-22,24,27H2,1-5H3/b29-23+. InChi Key: PLUINHYLFTYIKB-BYNJWEBRSA-N