Ganglioside GD1b (porcine) (sodium salt)

Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. This product contains ganglioside GD1b molecular species with primarily C18:0 fatty acyl chain lengths.CAS Number: 19553-76-5. Synonyms: Disialoganglioside GD1b, Ganglioside C1, Ganglioside G2. Molecular Formula: C84H146N4O39 . 2Na (for stearoyl). Formula Weight: 1836.1. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Chloroform:Methanol (2:1): Soluble, Water: Soluble. SMILES: CCCCCCCCCCCCC/C=C/[C@](O)([H])[C@@](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O[C@]3(O[C@H]([C@@H]([C@H](C3)O)NC(C)=O)[C@@H]([C@@H](CO)O[C@]4(O[C@H]([C@@H]([C@H](C4)O)NC(C)=O)[C@@H]([C@@H](CO)O)O)C([O-])=O)O)C([O-]. InChi Code: InChI=1S/C84H148N4O39.2Na/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-58(102)88-48(49(98)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2)44-116-78-69(110)67(108)71(56(42-93)119-78)121-80-70(111)76(72(57(43-94)120-80)122-77-61(87-47(5)97)73(64(105)54(4. InChi Key: ACTJLGSQQMVYGN-CSDJVHJJSA-L.