DSPE-PEG(2000)-tri-GalNAc

DSPE-PEG(2000)-tri-GalNAc is a multivalent N-acetylgalactosamine-conjugated lipid composed of an O-deacetylated derivative of LNP GalNAc ligand 1 (Cay-38952), a GABA linker, a PEG(2000) spacer, and 1,2-distearoyl-rac-glycero-3-phosphoethanolamine. Multivalent GalNAc-conjugated lipids have been used in the generation of lipid nanoparticles (LNPs) for targeted liver delivery via the asialoglycoprotein receptor (ASGPR). SMILES: O=C(NCCCNC(CCOCC(NC(CCCNC(CCCC(NCCCOCCOC(NCCOP(OCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@H](CO)[C@@H]1O)[C@H](NC(C)=O)[C@H]1O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]([C@@H]2NC(C)=O)O[C@@H]([C@@H]([C@@H]2O)O)CO)=O)=O)=O)CCCCO[C@@H]([C@@H]3NC(C)=O)O[C@@H]([C@@H]([C@@H]3O)O)CO