DSPE-PEG(2000) Cyanur

DSPE-PEG(2000) Cyanur is a PEGylated form of 1,2-distearoyl-sn-glycero-3-PE (DSPE, Cay-15095) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of micro RNA (miRNA) in vitro. LNPs containing DSPE-PEG(2000) cyanur, encapsulating let-7a miRNA, and conjugated to the Eph tyrosine kinase receptor (Eph) ligand ephrin-A1 reduce the proliferation and colony formation and size of NCI H2081, NCI 5380, and A549 lung cancer cells, as well as reduce migration of NCI 5380 cells in a wound healing assay.Formal Name: alpha-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-omega-[2-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]ethoxy]-poly(oxy-1,2-ethanediyl), monoammonium salt. CAS Number: 1246304-74-4. Synonyms: 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000 Cyanur, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-Polyethylene Glycol-2000 Cyanur, DSPE-Polyethylene Glycol-2000 Cyanur. Molecular Formula: (C2H4O)nC47H85Cl2N5O10P . NH4. Formula Weight: 1044.2. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(NCCOP([O-])(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC1=NC(Cl)=NC(Cl)=N1.[NH4+].