Drospirenone-13C3

Drospirenone-13C3 is intended for use as an internal standard for the quantification of drospirenone (Cay-23347) by GC- or LC-MS. Drospirenone is a synthetic progestogen. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously. Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone and luteinizing hormone (LH) in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.Formal Name: (4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-3',4,4a,4b,4',5,6,6a,7a,8,8a,8b,8c,8d,9,9a-hexadecahydro-5'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H)-dione-3',4',5'-13C3. Synonyms: 1,2-dihydro Spirorenone-13C3, ZK 30595-13C3. Molecular Formula: C21[13C]3H30O3. Formula Weight: 369.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble. SMILES: O=C1CC[C@@]2(C)C([C@@](C3)([H])[C@@]3([H])[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])[C@@](C6)([H])[C@@]6([H])[C@@]57[13CH2][13CH2][13C](O7)=O)=C1. InChi Code: InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1/i5+1,8+1,19+1. InChi Key: METQSPRSQINEEU-FYXUFONYSA-N.