DOG-IM4

DOG-IM4 is an ionizable cationic lipid (apparent pKa = 5.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Immunization with LNPs containing DOG-IM4 and encapsulating mRNA encoding influenza A hemagglutinin (HA) increases HA-inhibiting antibody titers (HI titers) in mice and cynomolgus macaques.InChI: InChI=1S/C51H95N3O7/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-59-46-49(61-37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)47-60-44-43-58-42-41-57-40-39-56-38-35-53-51(55)50-45-52-48-54-50/h17-20,45,48-49H,3-16,21-44,46-47H2,1-2H3,(H,52,54)(H,53,55)/b19-17-,20-18- InChIKey: QOSSCCSPDKDRPI-CLFAGFIQSA-N SMILES: CCCCCCCC/C=C\CCCCCCCCOC(COCCOCCOCCOCCNC(C1=CNC=N1)=O)COCCCCCCCC/C=C\CCCCCCCC