Docosahexaenoic Acid

Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils. It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes. DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from alpha-linolenic acid (ALA, Cay-90210, Cay-21910) via a series of desaturase- and elongase-catalyzed reactions, resulting in a docosapentaenoic acid (DPA, Cay-90165) intermediate, which is elongated, desaturated, and beta-oxidized to produce DHA. DHA can be liberated from cellular membranes by phospholipase A2 (PLA2) and converted to numerous oxylipins, including specialized pro-resolving mediators (SPMs), which are produced by lipoxygenases and include D-series protectins and resolvins, as well as maresins, that regulate host defense and the resolution of inflammation. DHA has roles in several physiological and pathological processes, including neural development, cardiovascular diseases, obesity, and inflammation.Formal Name: 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid. CAS Number: 6217-54-5. Synonyms: C22:6 n-3, C22:6(4Z,7Z,10Z,13Z,16Z,19Z), Cervonic Acid, DHA, 4,7,10,13,16,19-Docosahexaenoic Acid. Molecular Formula: C22H32O2. Formula Weight: 328.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.15 M Tris-HCl pH 8.5: >1 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): <100 µg/ml. SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O. InChi Code: InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-. InChi Key: MBMBGCFOFBJSGT-KUBAVDMBSA-N. Side Chain Carbon Sum: 22:6.