DMPE-PSar50-H

DMPE-PSar50-H is an amine-functionalized hydrophilic polymer and a polysarcosine-conjugated form of 1,2-dimyristoyl-sn-glycero-3-PE (1,2-DMPE, Cay-15090). Polysarcosines (PSars) have been used as alternatives to PEGylated lipids in lipid nanoparticles (LNPs). Liposomes containing PSar exhibit similar physicochemical properties in vitro to those containing PEGylated lipids but do not undergo the accelerated blood clearance (ABC) phenomenon and show reduced immunogenicity in rats. For more information, please see Curapath's white paper: Polysarcosine (PSar) a safer, more effective alternative to poly-ethylene glycol (PEG).