DMG-PEG(2000)

DMG-PEG(2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of fumarylacetoacetate hydrolase (FAH) mRNA in DMG-PEG(2000)-containing LNPs increases survival in a mouse model of hereditary tyrosinemia type 1 (HT-1). Formulations containing DMG-PEG(2000) have been used in the development of LNPs for the delivery of mRNA-based vaccines.Formal Name: alpha-[(2R)-2,3-bis[(1-oxotetradecyl)oxy]propyl]-omega-methoxy-poly(oxy-1,2-ethanediyl). CAS Number: 160743-62-4. Synonyms: 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000. Molecular Formula: (C2H4O)nC32H62O5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: slightly soluble, Ethanol: 1 mg/ml. SMILES: COCCOCC(COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O.