DMA4-H228

DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing DMA4-H228 selectively accumulate in antigen-presenting cells in the spleen in mice. DMA4-H228-containing LNPs encapsulating mRNA encoding ovalbumin induce activation of splenic antigen-presenting cells and increase serum levels of IFN-alpha in mice. LNPs containing DMA4-H228 and encapsulating mRNA encoding ovalbumin decrease tumor volume and increase intratumoral CD8+ T cells and serum anti-ovalbumin IgG titers in a B16/F10-OVA murine melanoma model. InChI: InChI=1S/C57H106N4O10/c1-6-10-14-18-22-26-40-60(41-27-23-19-15-11-7-2)52(62)32-34-54(64)68-47-49-70-56(66)37-45-59(44-36-51-31-30-39-58(51)5)46-38-57(67)71-50-48-69-55(65)35-33-53(63)61(42-28-24-20-16-12-8-3)43-29-25-21-17-13-9-4/h51H,6-50H2,1-5H3, InChIKey: OPRKPOFEXCTWIG-UHFFFAOYSA-N, SMILES: CCCCCCCCN(C(CCC(OCCOC(CCN(CCC1N(C)CCC1)CCC(OCCOC(CCC(N(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O)=O)=O)CCCCCCCC