Deoxaphomin

Deoxaphomin is a polyketide synthase-derived cytochalasin that has been found in P. semeniperda and has diverse biological activities. It inhibits anti-mouse IgG-induced capping in isolated mouse splenic lymphocytes by 70% when used at a concentration of 20 µM and inhibits actin filament elongation in C3H fibroblasts by 66% at 2 µM. Deoxaphomin (100 µM) inhibits seed germination and radicle growth induced by GR24 (Cay-13210) in the broomrapes O. crenata and P. ramosa. It inhibits the growth of OE21, U373 MG, SK-MEL-28, A549, B16/F10, and Hs 683 cancer cells (IC50s = 0. 1. 5. 2. and 0. µM, respectively).