CP-LC-1428

Lipid CP-LC-1428 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.. Formulation: A solution in ethanol. InChI: InChI=1S/C53H101N3O8S3/c1-9-11-13-18-26-46(25-12-10-2)43-64-52(60)32-41-66-39-30-48(53(61)54-34-35-56(7)8)55-49(57)28-20-19-27-47(67-42-33-51(59)63-37-22-15-17-24-45(5)6)29-38-65-40-31-50(58)62-36-21-14-16-23-44(3)4/h44-48H,9-43H2,1-8H3,(H,54,61)(H,55,57). InChIKey: KUHIDYRULVDIOR-UHFFFAOYSA-N. SMILES: O=C(NCCN(C)C)C(CCSCCC(OCC(CCCC)CCCCCC)=O)NC(CCCCC(CCSCCC(OCCCCCC(C)C)=O)SCCC(OCCCCCC(C)C)=O)=O