Commendamide

Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 µM.Formal Name: N-(3-hydroxy-1-oxohexadecyl)-glycine. CAS Number: 193825-78-4. Synonyms: N-acyl-3-hydroxypalmitoyl-Glycine. Molecular Formula: C18H35NO4. Formula Weight: 329.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C(O)CNC(CC(O)CCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C18H35NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(20)14-17(21)19-15-18(22)23/h16,20H,2-15H2,1H3,(H,19,21)(H,22,23). InChi Key: MZUHHHSFDVDBCZ-UHFFFAOYSA-N.