cKK-E15

cKK-E15 is an ionizable cationic lipid and a derivative of cKK-E12 (Cay-36700) that has been used in the generation of lipid nanoparticles (LNPs). LNPs containing cKK-E15 and encapsulating Cre mRNA induce the expression of Cre in Kupffer cells, endothelial cells, and hepatocytes in Ai14 mice engineered to express the fluorescent protein tdTomato upon translation of Cre. Translation of mRNA delivered to the liver by LNPs containing cKK-E15 is inhibited by the toll-like receptor 4 (TLR4) agonist LPS in Ai14 mice but not by low-grade chronic inflammation in a B16/F10 murine model of cancer-induced inflammation. Unlike cKK-E12, the delivery of LNPs containing cKK-E15 is not dependent upon ApoE or Ldlr expression in mice.Formal Name: 3,6-bis[4-[bis(2-hydroxypentadecyl)amino]butyl]-2,5-piperazinedione. CAS Number: 1432494-71-7. Molecular Formula: C72H144N4O6. Formula Weight: 1161.9. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 10 mg/ml. InChi Code: InChI=1S/C72H144N4O6/c1-5-9-13-17-21-25-29-33-37-41-45-53-65(77)61-75(62-66(78)54-46-42-38-34-30-26-22-18-14-10-6-2)59-51-49-57-69-71(81)74-70(72(82)73-69)58-50-52-60-76(63-67(79)55-47-43-39-35-31-27-23-19-15-11-7-3)64-68(80)56-48-44-40-36-32-28-24-20-16-12-8-4/h65-70,77-80H,5-64H2,1-4H3,(H,73,82)(H,74,81). InChi Key: FGDZRFPFIDLJAJ-UHFFFAOYSA-N.