Chikusetsusaponin IVa

Chikusetsusaponin IVa is an oleanane-type triterpenoid that has been found in P. stipuleanatus and has diverse biological activities. It inhibits the growth of human HL-60 leukemia and HCT116 colon cancer cells (IC50s = 76.23 and 78.11 µM, respectively). Chikusetsusaponin IVa (50-200 µg/ml) reduces LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, IL-1beta, IL-6, and TNF-alpha levels in THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA, Cay-10008014). It decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of type 2 diabetes induced by streptozotocin (STZ, Cay-13104) and a high-fat diet when administered at doses ranging from 45 to 180 mg/kg. It also decreases malondialdehyde (MDA), and increases superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase 4 (GPX4), levels in the pancreas in the same model.Formal Name: (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid. CAS Number: 51415-02-2. Synonyms: Chikusetsu Saponin IVa, Chi IVa. Molecular Formula: C42H66O14. Formula Weight: 795.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC([C@]23[C@](CC(C)(CC3)C)([H])C4=CC[C@@]([C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)C)([H])CC7)C)([H])[C@]7(C)[C@@]4(CC2)C)=O. InChi Code: InChI=1S/C42H66O14/c1-37(2)14-16-42(36(52)56-34-30(48)27(45)26(44)22(19-43)53-34)17-15-40(6)20(21(42)18-37)8-9-24-39(5)12-11-25(38(3,4)23(39)10-13-41(24,40)7)54-35-31(49)28(46)29(47)32(55-35)33(50)51/h8,21-32,34-35,43-49H,9-19H2,1-7H3,(H,50,51)/t21-,22+,23-,24+,25-,26+,27-,28-,29-,30+,31+,32-,34-,35+,39-,40+,41+,42-/m0/s1. InChi Key: YOSRLTNUOCHBEA-SGVKAIFKSA-N. Origin: Plant/Panax pseudoginseng.