Chelidonic Acid

Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities. It inhibits rat brain glutamate decarboxylase (Ki = 1.2 µM). Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-alpha levels, colonic COX-2 and prostaglandin E2 (PGE2, Cay-14010) levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS, Cay-23250). It inhibits ovalbumin challenge-induced decreases in spleen IFN-gamma levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.Formal Name: 4-oxo-4H-pyran-2,6-dicarboxylic acid. CAS Number: 99-32-1. Synonyms: NSC 3979. Molecular Formula: C7H4O6. Formula Weight: 184.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 220, 272 nm. SMILES: O=C1C=C(C(O)=O)OC(C(O)=O)=C1. InChi Code: InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12). InChi Key: PBAYDYUZOSNJGU-UHFFFAOYSA-N. Origin: Synthetic.