C8 Galactosylceramide (d18:1/8:0)

C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin (Cay-15007) in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo. It also activates NF-kappaB production in C6 glioma cells when used at a concentration of 10 µM. [Matreya, LLC. Catalog No. 1334]Formal Name: N-[(1S,2R,3E)-1-[(beta-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-octanamide. CAS Number: 41613-16-5. Synonyms: Galactosylceramide (d18:1/8:0), N-octanoyl-beta-D-Galactosylceramide, GalCer(d18:1/8:0). Molecular Formula: C32H61NO8. Formula Weight: 587.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (9:1): soluble, Ethanol: soluble, Methanol: soluble. SMILES: O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O. InChi Code: InChI=1S/C32H61NO8/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-26(35)25(33-28(36)22-20-17-8-6-4-2)24-40-32-31(39)30(38)29(37)27(23-34)41-32/h19,21,25-27,29-32,34-35,37-39H,3-18,20,22-24H2,1-2H3,(H,33,36)/b21-19+/t25-,26+,27+,29-,30-,31+,32+/m0/s1. InChi Key: LCEXEEHGNKGJES-SWMJIITPSA-N.