C6 D-threo Ceramide (d18:1/6:0)

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 µM). It is metabolically inactive and, unlike C6 L-erythro ceramide (Cay-24388), C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 µM but induces cell death at concentrations greater than 5 µM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in EL4 T cells when used at a concentration of 10 µM. [Matreya, LLC. Catalog No. 1809]Formal Name: N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexanamide. CAS Number: 189894-79-9. Synonyms: N-hexanoyl-D-threo-Sphingosine, D-threo Cer(d18:1/6:0), D-threo Ceramide (d18:1/6:0). Molecular Formula: C24H47NO3. Formula Weight: 397.6. Purity: >98%. Formulation: (Request formulation change), A solid. SMILES: OC[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCC)=O. InChi Code: InChI=1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+/t22-,23-/m1/s1. InChi Key: NPRJSFWNFTXXQC-KHZUJUORSA-N.