C6 Ceramide-d7 (d18:1-d7/6:0)

C6 Ceramide-d7 is intended for use as an internal standard for the quantification of short-chain ceramides, such as C2 ceramide (Cay-62510, Cay-24386, Cay-24387), C6 ceramide (Cay-62525), and C8 ceramide (Cay-62540, Cay-24391, Cay-24392), by GC- or LC-MS. C6 Ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 Ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 Ceramide acts in neuronal axons to inhibit neurite growth.Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-15,15,16,16,17,17,17-d7]-hexanamide. CAS Number: 2692624-22-7. Synonyms: N-Caproyl-C18-Sphingosine-d7, Cer-d7(d18:1-d7/6:0), C6 Ceramide-d7, Ceramide-d7 (d18:1-d7/6:0), N-hexanoyl-D-erythro-Sphingosine-d7. Molecular Formula: C24H40D7NO3. Formula Weight: 404.7. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: >22 mg/ml, DMSO: >20 mg/ml, Ethanol: >33 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml, PBS (pH 7.2): <50 µg/ml. SMILES: OC[C@H](NC(CCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]. InChi Code: InChI=1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+/t22-,23+/m0/s1/i1D3,3D2,5D2. InChi Key: NPRJSFWNFTXXQC-OMMXNDSESA-N.