BLT-1

BLT-1 is an inhibitor of scavenger receptor B1 (SR-BI). It inhibits uptake of [3H]cholesteryl ester-HDL in LDL receptor-deficient CHO cells expressing mouse SR-BI ((ldlA[mSR-BI]) cells, IC50 = 0.11 µM) and the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC50 = 0.15 µM). BLT-1 (8 µM) induces developmental defects in zebrafish embryos, an effect that can be prevented by copper chloride.Formal Name: 2-(2-hexylcyclopentylidene)-hydrazinecarbothioamide. CAS Number: 321673-30-7. Synonyms: Block Lipid Transport-1. Molecular Formula: C12H23N3S. Formula Weight: 241.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 11 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 273 nm. SMILES: S=C(NN=C1CCCC1CCCCCC)N. InChi Code: InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16). InChi Key: OWGUSBISUVLUJF-UHFFFAOYSA-N.