beta-Muricholic Acid-d4

beta-Muricholic acid-d4 (beta-MCA-d4) is intended for use as an internal standard for the quantification of beta-muricholic acid (Cay-20287) by GC- or LC-MS. beta-MCA is a murine-specific primary bile acid. Dietary administration of beta-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of beta-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.Formal Name: (5beta)-3alpha,6beta,7beta-trihydroxy-cholan-2,2,4,4-d4-24-oic acid. Synonyms: 5beta-Cholanic Acid-3alpha,6beta,7beta-triol-d4, beta-MCA-d4. Molecular Formula: C24H36D4O5. Formula Weight: 412.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: OC(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C)=O. InChi Code: InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21+,22-,23-,24-/m1/s1/i8D2,12D2. InChi Key: DKPMWHFRUGMUKF-APBBRSFGSA-N.