Apigenin 7-O-Glucuronide (hydrate)

Apigenin 7-O-glucuronide is a flavonoid that has been found in J. sigillata and has diverse biological activities. It inhibits matrix metalloproteinase-3 (MMP-3), MMP-8, MMP-9, and MMP-13 (IC50s = 12.87, 22.39, 17.52, and 0.27 µM, respectively). Apigenin 7-O-glucuronide also inhibits protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and aldose reductase with IC50 values of 7.14, 62.96, and 107.1 µM, respectively. It inhibits LPS-induced production of nitric oxide, prostaglandin E2 (PGE2, Cay-14010), and TNF-alpha in RAW 264.7 cells when used at a concentration of 100 µM. Apigenin 7-O-glucuronide (5 or 10 mg/kg) improves survival in a mouse model of septic shock induced by LPS.Formal Name: beta-D-glucopyranosiduronic acid, 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, hydrate. Molecular Formula: C21H18O11 . XH2O. Formula Weight: 446.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 270, 335 nm. SMILES: O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)C=C2OC(C4=CC=C(C=C4)O)=C1.O. InChi Code: InChI=1S/C21H18O11.H2O/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29,/h1-7,16-19,21-23,25-27H,(H,28,29),1H2/t16-,17-,18+,19-,21+,/m0./s1. InChi Key: XODLIZARORJIDL-ZSESPEEFSA-N. Origin: Plant/Ixeris sonchifolia.