alpha-Mangostin

alpha-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities. It inhibits fatty acid synthase and HIV-1 protease (IC50s = 5.54 and 5.12 µM, respectively). alpha-Mangostin is active against methicillin-sensitive and -resistant S. aureus strains (MICs = 1.57-12.5 µg/ml). It inhibits nitric oxide and prostaglandin E2 (PGE2, Cay-14010) production in LPS-stimulated RAW 264.7 cells (IC50s = 12.4 and 11.08 µM, respectively). alpha-Mangostin is an agonist of stimulator of interferon genes (STING) that binds to the C-terminal domain of STING (H232 variant) with a Kd value of 137 µM and induces expression of an IFN-beta-luciferase reporter in HEK293T cells transfected with human STING (H232 variant) to a greater extent than cells expressing murine STING or human STING (R232 variant) when used at a concentration of 25 µM. alpha-Mangostin (20 mg/kg) prevents carrageenan-induced paw edema in mice. It decreases the viability of LNCaP, 22Rv1, DU145, and PC3 prostate cancer cells in vitro (IC50s = 5.9, 6.9, 22.5, and 12.7 µM, respectively) and reduces tumor growth in a 22Rv1 mouse xenograft model when administered at a dose of 100 mg/kg.Formal Name: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one. CAS Number: 6147-11-1. Synonyms: NSC 27593, NSC 139154. Molecular Formula: C24H26O6. Formula Weight: 410.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 245, 318 nm. SMILES: OC1=C2C(OC(C=C(O)C(OC)=C3C/C=C(C)/C)=C3C2=O)=CC(O)=C1C/C=C(C)/C. InChi Code: InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3. InChi Key: GNRIZKKCNOBBMO-UHFFFAOYSA-N. Origin: Plant/Garcinia mangostana L..