AA3-DLin

AA3-DLin is an ionizable cationic amino lipid (pKa = 5.8) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing AA3-DLin and encapsulating mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein induce immunogenicity in mice.Formal Name: piperazine-1,4-diylbis(ethane-2,1-diyl) (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate). Molecular Formula: C44H78N2O4. Formula Weight: 699.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 25 mg/ml. SMILES: O=C(CCCCCCC/C=C\C/C=C\CCCCC)OCCN1CCN(CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CC1. InChi Code: InChI=1S/C44H78N2O4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-43(47)49-41-39-45-35-37-46(38-36-45)40-42-50-44(48)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20H,3-10,15-16,21-42H2,1-2H3/b13-11-,14-12-,19-17-,20-18-. InChi Key: LJCULYBZRITLON-MAZCIEHSSA-N.