9(Z),11(E)-Conjugated Linoleic Acid

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) that has been found in beef and milk fat. It binds to peroxisome proliferator-activated receptor alpha (PPARalpha, IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARalpha when used at a concentration of 100 µM. 9(Z),11(E)-Conjugated linoleic acid inhibits TNF-alpha-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes. Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice. It also increases body weight gain and body fat in weanling mice. [Matreya, LLC. Catalog No. 1245]Formal Name: 9Z,11E-octadecadienoic acid. CAS Number: 2540-56-9. Synonyms: 9Z,11E-CLA, cis-9,trans-11-Conjugated Linoleic Acid, FA 18:2. Molecular Formula: C18H32O2. Formula Weight: 280.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid), DMF: >100 mg/ml (from Oleic Acid), DMSO: >100 mg/ml (from Oleic Acid), Ethanol: >100 mg/ml (from Oleic Acid), PBS pH 7.2: <100 µg/ml (from Oleic Acid). lambdamax: 233 nm. SMILES: CCCCCC/C=C/C=C\CCCCCCCC(O)=O. InChi Code: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9-. InChi Key: JBYXPOFIGCOSSB-GOJKSUSPSA-N. Side Chain Carbon Sum: 18:2.