5alpha-Dihydroprogesterone

5alpha-Dihydroprogesterone (5alpha-DHP) is a progesterone receptor agonist and metabolite of progesterone (Cay-15876). It is formed from progesterone by 5alpha-reductase. It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively). 5alpha-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner. 5alpha-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.Formal Name: (5alpha)-pregnane-3,20-dione. CAS Number: 566-65-4. Synonyms: 5alpha-DHP, NSC 18319, 5alpha-Pregnanedione. Molecular Formula: C21H32O2. Formula Weight: 316.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 30 mg/ml. SMILES: C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C. InChi Code: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1. InChi Key: XMRPGKVKISIQBV-BJMCWZGWSA-N.