5-O-Demethylnobiletin

5-O-Demethylnobiletin is a flavonoid that has been found in S. tragoriganum and has diverse biological activities. It induces neurite outgrowth and the expression of the genes encoding the neuronal differentiation and synapse formation markers growth-associated protein 43 (GAP43) and synaptophysin in PC12 cells when used at concentrations ranging from 10 to 20 µM. 5-O-Demethylnobiletin (2.5-20 µM) reduces triglyceride levels in 3T3-L1 preadipocytes and decreases body weight, intra-abdominal fat, plasma and liver triglyceride levels, and plasma cholesterol levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 25 mg/kg. It reduces hepatic fibrosis and malondialdehyde (MDA) levels in a mouse model of carbon tetrachloride-induced liver injury. 5-O-Demethylnobiletin also reduces ear edema, inflammatory cell infiltration, and papillar fibrosis in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014).Formal Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one. CAS Number: 2174-59-6. Synonyms: 5-hydroxy Nob, NSC 618927. Molecular Formula: C20H20O8. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 253, 284, 339 nm. SMILES: O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=C(C(OC)=C(C(O)=C13)OC)OC. InChi Code: InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3. InChi Key: DOFJNFPSMUCECH-UHFFFAOYSA-N. Origin: Plant/Citrus reticulata Blanco.