4A3-SCC-10

4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.Formal Name: ((methylazanediyl)bis(propane-3,1-diyl))bis(8,14-dioxo-7,15-dioxa-3,4,18,19-tetrathia-11-azahenicosane-11,1,21-triyl) tetrakis(3-(decylthio)-2-methylpropanoate). Molecular Formula: C91H171N3O16S12. Formula Weight: 1948.1. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: CN(CCCN(CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCCN(CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O. InChi Code: InChI=1S/C91H171N3O16S12/c1-10-14-18-22-26-30-34-38-64-111-76-80(5)88(99)107-60-72-119-115-68-56-103-84(95)44-52-93(53-45-85(96)104-57-69-116-120-73-61-108-89(100)81(6)77-112-65-39-35-31-27-23-19-15-11-2)50-42-48-92(9)49-43-51-94(54-46-86(97)105-58-70-117-121-74-62-109-90(101)82(7)78-113-66-40-36-32-28-24-20-16-12-3)55-47-87(98)106-59-71-118-122-75-63-110-91(102)83(8)79-114-67-41-37-33-29-25-21-17-13-4/h80-83H,10-79H2,1-9H3. InChi Key: KTIRKMBPBLQRPY-UHFFFAOYSA-N.