4-hydroxy Nonenal Alkyne

4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of omega-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid. It is considered a potential causal agent in numerous diseases, including chronic inflammation, neurodegenerative diseases, atherosclerosis, diabetes, and cancer, in part because it covalently modifies DNA and proteins resulting in genetic mutations and altered cell signaling, respectively. 4-HNE alkyne is a form of 4-HNE with a terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.Formal Name: 4-hydroxynon-2E-nonen-8-ynal. CAS Number: 1011268-23-7. Synonyms: Click Tag(TM) 4-HNE Alkyne. Molecular Formula: C9H12O2. Formula Weight: 152.2. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 2.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 12.5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 220 nm. SMILES: [H]C(/C=C/C(O)CCCC#C)=O. InChi Code: InChI=1S/C9H12O2/c1-2-3-4-6-9(11)7-5-8-10/h1,5,7-9,11H,3-4,6H2/b7-5+. InChi Key: RXECVCDYORIBBT-FNORWQNLSA-N.