2008-11-10 00:00:00

11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo. LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.Formal Name: ((2-(pyrrolidin-1-yl)ethyl)azanediyl)bis(decane-1,2-diyl) dioctanoate. Molecular Formula: C42H82N2O4. Formula Weight: 679.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: O=C(CCCCCCC)OC(CCCCCCCC)CN(CCN1CCCC1)CC(CCCCCCCC)OC(CCCCCCC)=O. InChi Code: InChI=1S/C42H82N2O4/c1-5-9-13-17-21-23-29-39(47-41(45)31-25-19-15-11-7-3)37-44(36-35-43-33-27-28-34-43)38-40(30-24-22-18-14-10-6-2)48-42(46)32-26-20-16-12-8-4/h39-40H,5-38H2,1-4H3. InChi Key: LRBLCOLXDIPVSZ-UHFFFAOYSA-N.