2,3-dinor Thromboxane B2-d9

2,3-dinor Thromboxane B2-d9 (2,3-dinor TXB2-d9) is intended for use as an internal standard for the quantification of 2,3-dinor TXB2 (Cay-19050) by GC- or LC-MS. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis. In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).Formal Name: (Z)-5-((2R,3S,4S)-4,6-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl-5,5,6,6,7,7,8,8,8-d9)tetrahydro-2H-pyran-3-yl)pent-3-enoic acid. Synonyms: 2,3-dinor TXB2-d9. Molecular Formula: C18H21D9O6. Formula Weight: 351.5. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >50 mg/mL, DMSO: >25 mg/mL, Ethanol: >100 mg/mL, PBS (pH 7.2): >100 mg/mL. SMILES: O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])OC(O)C1. InChi Code: InChI=1S/C18H30O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,18-20,23H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+,18?/m0/s1/i1D3,2D2,3D2,4D2. InChi Key: RJHNVFKNIJQTQF-NADUYOJDSA-N.