17beta-Estradiol-d3

17beta-Estradiol-d3 is intended for use as an internal standard for the quantification of 17beta-estradiol (Cay-ISO60155, Cay-10006315). 17beta-Estradiol is the major pre-menopausal bioactive estrogen and an active metabolite of testosterone. It is produced primarily by the ovary, and to a lesser extent, by the adrenals, testes, and adipose tissue, as well as by the placenta during pregnancy. 17beta-Estradiol binds to estrogen receptors localized to the nucleus, cytoplasm, and plasma membrane and induces gene transcription or non-genomic intracellular signaling in a location-dependent manner. It regulates reproductive development in females and spermatogenesis in males, as well as various non-reproductive processes including lipid and glucose homeostasis, bone mass maintenance, cognition, energy balance, and dilation of blood vessels. 17beta-Estradiol deficiency due to hypogonadism or 17alpha-hydroxylase/17,20-lyase deficiency is associated with fatigue, incontinence, osteoporosis, depression, emotional instability, and hot flashes.Formal Name: estra-1,3,5(10)-triene-16,16,17-d3-3,17beta-diol. CAS Number: 79037-37-9. Synonyms: E2-d3, Estradiol-d3, beta-Estradiol-d3, 17beta-Oestradiol-d3. Molecular Formula: C18H21D3O2. Formula Weight: 275.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: C[C@@]12[C@](CC([2H])([2H])[C@]2([2H])O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3. InChi Code: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1/i7D2,17D. InChi Key: VOXZDWNPVJITMN-SPGJGCHISA-N.