17beta-Estradiol-d2

17beta-Estradiol-d2 is intended for use as an internal standard for the quantification of 17beta-estradiol (Cay-ISO60155, Cay-10006315) by GC- or LC-MS. 17beta-Estradiol is the major pre-menopausal bioactive estrogen and an active metabolite of testosterone. It is produced primarily by the ovary, and to a lesser extent, by the adrenals, testes, and adipose tissue, as well as by the placenta during pregnancy. 17beta-Estradiol binds to estrogen receptors localized to the nucleus, cytoplasm, and plasma membrane and induces gene transcription or non-genomic intracellular signaling in a location-dependent manner. It regulates reproductive development in females and spermatogenesis in males, as well as various non-reproductive processes including lipid and glucose homeostasis, bone mass maintenance, cognition, energy balance, and dilation of blood vessels. 17beta-Estradiol deficiency due to hypogonadism or 17alpha-hydroxylase/17,20-lyase deficiency is associated with fatigue, incontinence, osteoporosis, depression, emotional instability, and hot flashes.Formal Name: estra-1,3,5(10)-triene-2,4-d2-3,17beta-diol. CAS Number: 53866-33-4. Synonyms: 2,4-Dideuteriostradiol, E2-d2, Estradiol-d2, beta-Estradiol-d2, 17beta-Oestradiol-d2. Molecular Formula: C18H22D2O2. Formula Weight: 274.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 2 mg/ml. lambdamax: 281 nm. SMILES: OC1=C([2H])C=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=C1[2H]. InChi Code: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1/i3D,10D. InChi Key: VOXZDWNPVJITMN-JXCLBMSPSA-N.