17(R)-Resolvin D1-d5

17(R)-Resolvin D1-d5 (17(R)-RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 by GC- or LC-MS. 17(R)-RvD1 is formed by aspirin-acetylated COX-2-mediated oxidation of docosahexaenoic acid (DHA, Cay-90310, Cay-17950) via a 17(R)-HDHA (Cay-10005099) intermediate, which is oxygenated by 5-lipoxygenase (5-LO). 17(S)-RvD1 is formed from the sequential oxygenation of DHA by 15- and 5-LO via a 17(S)-hydroxy-DHA (17(S)-HDHA, Cay-10009799) intermediate.Formal Name: 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21,22,22,22-d5 docosahexaenoic acid. Synonyms: Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5. Molecular Formula: C22H27D5O5. Formula Weight: 381.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): .05 mg/ml. lambdamax: 289, 302, 316 nm. SMILES: O[C@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21+/m1/s1/i1D3,2D2. InChi Key: OIWTWACQMDFHJG-ZHLHUWGTSA-N.