17(R)-Resolvin D1

17(R)-Resolvin D1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay13060-10 10 µg -

5 - 10 Werktage*

157,00 €
Cay13060-25 25 µg -

5 - 10 Werktage*

372,00 €
Cay13060-50 50 µg -

5 - 10 Werktage*

704,00 €
Cay13060-100 100 µg -

5 - 10 Werktage*

1.235,00 €
 
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA,... mehr
Produktinformationen "17(R)-Resolvin D1"
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1, Cay-10012554) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose. In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product. Formal Name: 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid. CAS Number: 528583-91-7. Synonyms: Aspirin-triggered Resolvin D1, 17-epi-Resolvin D1, AT-RvD1, 17(R)-RvD1. Molecular Formula: C22H32O5. Formula Weight: 376.5. Purity: >95%. Formulation: A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.05 mg/ml. lambdamax: 302 nm. SMILES: CC/C=C\C[C@@H](O)\C=C\C=C\C=C/C=C\[C@@H](O)C(O)C/C=C\CCC(=O)O. InChi Code: InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21+/m1/s1. InChi Key: OIWTWACQMDFHJG-BJEBZIPWSA-N.
Schlagworte: 17(R)-RvD1, 17-epi-Resolvin D1, Aspirin-triggered Resolvin D1, AT-RvD1, 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 13060

Eigenschaften

Anwendung: Bioactive lipid assays
MW: 376.5 D
Formel: C22H32O5
Reinheit: >95%
Format: Solution

Datenbank Information

CAS : 528583-91-7| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225
P-Sätze: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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