15-keto Latanoprost

15-keto Latanoprost is an active metabolite of the FP receptor agonist latanoprost (Cay-16812). Intraocular administration of 15-keto latanoprost (1 µg/eye) reduces intraocular pressure in cynomolgus monkeys. It also reduces pupillary diameter in cats when administered topically at a dose of 5 µg/eye. 15-keto Latanoprost is a potential pharmaceutical impurity found in commercial preparations of latanoprost.Formal Name: 9alpha,11alpha-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic acid, isopropyl ester. CAS Number: 135646-98-9. Molecular Formula: C26H38O5. Formula Weight: 430.6. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, DMSO:PBS (1:12): 80 µg/ml, Ethanol: 100 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CCC(CCC2=CC=CC=C2)=O)[C@H](O)C1. InChi Code: InChI=1S/C26H38O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,22-25,28-29H,4,9,12-18H2,1-2H3/b8-3-/t22-,23-,24+,25-/m1/s1. InChi Key: DKYCMQSMHPIBBZ-VIZYZFHWSA-N.