1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC

1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC is a lysophospholipid containing docosahexaenoic acid (DHA, Cay-90310, Cay-17950) at the sn-1 position that has been found in shark liver extract. 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC decreases LPS-induced increases in TNF-alpha and IL-6 levels in RAW 264.7 cells in a concentration-dependent manner. It decreases LPS-induced production of nitric oxide (NO) in RAW 264.7 cells when used at concentrations ranging from 12 to 200 µM. 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC (15-500 µg/kg) inhibits plasma leakage into the peritoneum in a mouse model of peritonitis induced by zymosan A (Cay-21175).Formal Name: 4,7R-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahentriaconta-13Z,16Z,19Z,22Z,25Z,28Z-hexaen-1-aminium, 4-oxide, inner salt. CAS Number: 162440-05-3. Synonyms: 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-Phosphocholine, LysoPC(22:6/0:0), PC(22:6/0:0), 22:6/0:0-PC. Molecular Formula: C30H50NO7P. Formula Weight: 567.7. Purity: >90%. Formulation: (Request formulation change), A solution in chloroform. Solubility: Chloroform: 10 mg/ml. SMILES: O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O. InChi Code: InChI=1S/C30H50NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-30(33)36-27-29(32)28-38-39(34,35)37-26-25-31(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,29,32H,5,8,11,14,17,20,23-28H2,1-4H3/b7-6-,10-9-,13-12-,16-15-,19-18-,22-21-/t29-/m1/s1. InChi Key: LSOWKZULVQWMLY-APPDJCNMSA-N.