1-A-N

1-A-N is an ionizable cationic lipid (pKa = 6.8) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vivo. LNPs containing 1-A-N and encapsulating siRNA targeting the gene encoding CD45 reduce its gene expression in splenic T cells in mice.Formal Name: 3-(2-((3r,5r,7r)-adamantan-1-yl)acetoxy)-2-((((3-(pyrrolidin-1-yl)propoxy)carbonyl)oxy)methyl)propyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate. Molecular Formula: C42H67NO7. Formula Weight: 698.0. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble, Methanol: Soluble. SMILES: CC/C=C\C/C=C\C/C=C\CCCCCCCC(OCC(COC(OCCCN1CCCC1)=O)COC(CC23C[C@@H]4C[C@@H](C[C@H](C3)C4)C2)=O)=O. InChi Code: InChI=1S/C42H67NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-39(44)48-32-38(34-50-41(46)47-24-19-23-43-21-17-18-22-43)33-49-40(45)31-42-28-35-25-36(29-42)27-37(26-35)30-42/h3-4,6-7,9-10,35-38H,2,5,8,11-34H2,1H3/b4-3-,7-6-,10-9-/t35-,36+,37-,38?,42?. InChi Key: BBSUYHMNTQALBM-OARARTKKSA-N.