1,2-Distearoyl-sn-glycero-3-phosphoserine (sodium salt)

1,2-Distearoyl-sn-glycero-3-phosphoserine (1,2-DSPS) is a phospholipid containing stearic acid (Cay-10011298) at the sn-1 and sn-2 positions. It has been used in the generation of liposomal nanoparticles for the delivery of siRNA in vitro. Liposomal nanoparticles containing 1,2-DSPS and encapsulating siRNA targeting c-Rel decrease c-Rel levels in primary mouse macrophages. Formal Name: (2S,8R)-4,6,10-trioxa-5-phosphaoctacosanoic acid, 2-amino-5-hydroxy-11-oxo-8-[(1-oxooctadecyl)oxy]-5-oxide, sodium salt. CAS Number: 321595-13-5. Synonyms: 1,2-Dioctadecanoyl-sn-glycero-3-phosphoserine 1,2-Distearoyl Phosphatidylserine 1,2-DSPS PS(C18:0/C18:0) PtdSer-(1,2-distearoyl). Molecular Formula: C42H81NO10P  xNa. Formula Weight: 791.1. Purity: >90%. Formulation: A solid. Solubility: Chloroform:Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCCCC)=O)COP(OC[C@H]([NH3+])C([O-])=O)([O-])=O.[Na+]. InChi Code: InChI=1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2,/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49),/q,+1/p-1/t38-,39+,/m1./s1. InChi Key: SJRBMGBLPUBGJL-MBAWARMDSA-M. Storage: -20°C. Stability: > 4 years.