1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)

1,2-Dioleoyl-sn-glycero-3-PS (1,2-DOPS) is a phospholipid containing oleic acid (Cay-90260, Cay-24659) at the sn-1 and sn-2 positions, respectively. Nanovesicles composed of 1,2-DOPS and the lysosomal protein saposin C (SapC) are cytotoxic to SK-MEL-28 cells in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model. 1,2-DOPS has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets.Formal Name: (2S,8R,19Z)-2-amino-5-hydroxy-11-oxo-8-[[(9Z)-1-oxo-9-octadecenyl]oxy]-4,6,10-trioxa-5-phosphaoctacos-19-enoic acid, 5-oxide, monosodium salt. CAS Number: 90693-88-2. Synonyms: 1,2-DOPS, 18:1/18:1-PS, PS(18:1/18:1), 1,2-Dioctadecenoyl-sn-glycero-3-Phosphoserine, 1,2-Dioctadecenoyl-sn-glycero-3-Phosphatidylserine. Molecular Formula: C42H77NO10P . Na. Formula Weight: 810.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml. SMILES: CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(OC[C@H](N)C(O)=O)([O-])=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Na+]. InChi Code: InChI=1S/C42H78NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2,/h17-20,38-39H,3-16,21-37,43H2,1-2H3,(H,46,47)(H,48,49),/q,+1/p-1/b19-17-,20-18-,/t38-,39+,/m1./s1. InChi Key: KPHZNDUWYZIXFY-YORIBCANSA-M.