Sunnyvale Red(TM) SE *Superior 6-ROX Replacement*

Although ROX dyes have strong fluorescence they are notoriously unstable. Some commercial samples only have a few months shelf life. Compared to 6-ROX labeling compounds our Sunnyvale Red(TM) dyes have greatly enhanced stability while they have essentially identical spectral properties to those of 6-ROX when conjugated to a biological substrate (such as oligonucleotides). Our preliminary studies indicated that Sunnyvale Red-derived oligos are more easily purified than the corresponding 6-ROX oligos in some cases.