ZZL-7

Description: ZZL-7 is a fast-onset antidepressant agent that disrupts the interaction between neuronal nitric oxide synthase (nNOS) and the serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). It easily crosses the blood-brain barrier and has research value in major depressive disorder (MDD). Target: Serotonin Transporter. Smiles: COC(=O)[C@@H](NC(=O)[C@H](C)NC(C)=O)C(C)C. References: Nan Sun, et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science. 2022 Oct 28,378(6618):390-398.