Zeaxanthin Dipalmitate

Zeaxanthin dipalmitate is a carotenoid that has been found in F. lycii and has hepatoprotective activity. It inhibits TGF-beta-induced activation of hepatic stellate cells (IC50 = 186.34 µM). Zeaxanthin (25 mg/kg) reduces hepatic collagen deposition and levels of thiobarbituric acid reactive substances (TBARS), as well as the activity of serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP), in a rat model of hepatic fibrosis induced by bile duct ligation. It also decreases reactivated levels of hepatitis B virus (HBV) DNA and reduces hepatic steatosis, inflammation, and fibrosis in a model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient diet in HBV transgenic mice.Formal Name: (3R,3'R)-beta,beta-carotene-3,3'-diol, 3,3'-dihexadecanoate. CAS Number: 144-67-2. Synonyms: Physalien. Molecular Formula: C72H116O4. Formula Weight: 1045.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: slightly soluble. SMILES: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](OC(CCCCCCCCCCCCCCC)=O)CC2(C)C)=C(C)C[C@@H](OC(CCCCCCCCCCCCCCC)=O)C1. InChi Code: InChI=1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-54,65-66H,13-38,49-50,55-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+/t65-,66-/m1/s1. InChi Key: XACHQDDXHDTRLX-XLVVAOPESA-N. Origin: Synthetic.