ZCL279

Description: ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 µM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 µM) it significantly inhibits it. Target: Ras. Smiles: O=S(=O)(NC=1C=CC=CC1O)C=2C=CC=3OC4=CC=C(C=C4C3C2)S(=O)(=O)NC=5C=CC=CC5O