Z16078526

Description: Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gene expression and mitochondrial activity, specifically uncoupled respiration, in these cells. Target: p38 MAPK, Mitochondrial Metabolism. Smiles: O=C1C=2C(NC(SCC(NC3=C(OC)C=C(OC)C=C3)=O)=N1)=CC=CC2. References: Vergnes L, et al. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30,295(44):15054-15069.